Amygdalohippocampal Deep Brain Stimulation (Ah-DBS) for Refractory Temporal Lobe Epilepsy

Four patients had a left-sided focal medial temporal lobe onset. Three patients had a right-sided regional medial temporal lobe onset. One patient had a bilateral regional temporal lobe onset with predominant involvement of the left side. Two patients had a leftsided regional medial temporal lobe onset. Nine out of 10 patients had a >50% reduction of interictal spikes during the initial AH-DBS trial period. In one patient who showed very infrequent spiking, seizure frequency that had significantly decreased, was used as a criterion for implantation. One patient did not meet the chronic implantation criterion and underwent a selective amygdalo-hippocampectomy. Nine out of 10 patients were implanted with an internal generator. The mean follow-up in these patients was 16 months (range: 9–25 months). One patient has been free of complex partial seizures (CPS) for 2 years and has been tapered off 2 anti-epileptic drugs (AEDs). Another patient has become seizure-free in the past 9 months; 3/10 patients have a >50% reduction in seizure frequency; 3/4 patients have been taIntroduction